Product Description

🔹 Product Overview
LEUCROIN 5 mL Injection is a prescription medicine containing Leucovorin Calcium (Calcium Folinate), used as supportive therapy in oncology and in the management of folate deficiency. It is commonly administered to reduce the toxic effects of high-dose methotrexate therapy, enhance the effectiveness of fluorouracil (5-FU) in certain cancers, and treat folate deficiency when oral therapy is not suitable. It is administered under the supervision of a qualified healthcare professional.

🔹 Key Uses
Rescue therapy after high-dose methotrexate treatment
Reduces the harmful effects of methotrexate toxicity
Used in combination with fluorouracil (5-FU) for colorectal cancer treatment
Treatment of folate deficiency when appropriate
Management of accidental overdose of folic acid antagonists as advised by a physician
Supportive care in selected chemotherapy regimens

🔹 Composition
Active Ingredient:
Leucovorin Calcium (Calcium Folinate) 50 mg/5 mL
Drug Class:
Folinic Acid Derivative
Antidote / Chemotherapy Supportive Medicine
Dosage Form:
Injection
Pack Size:
5 mL Vial

🔹 How It Works
Leucovorin is the active form of folic acid that bypasses blocked folate metabolism. It protects healthy cells from the toxic effects of medicines such as methotrexate while allowing the anticancer treatment to remain effective. When combined with fluorouracil (5-FU), it enhances the anticancer activity of the chemotherapy medicine.

🔹 Key Benefits
Helps reduce methotrexate-related toxicity
Supports healthy cell recovery during chemotherapy
Enhances the effectiveness of fluorouracil in selected cancers
Treats folate deficiency when injectable therapy is required
Administered under specialist medical supervision
Important supportive medicine in oncology treatment protocols

🔹 Dosage and Administration
Use only under the supervision of an oncologist or healthcare professional.
Administered by intravenous (IV) or intramuscular (IM) injection, depending on the treatment protocol.
The dose and duration are based on the patient's condition, body weight, laboratory results, and chemotherapy regimen.
Regular blood tests may be required during treatment.
Do not self-administer unless specifically instructed by a healthcare professional.

🔹 Possible Side Effects
Common side effects may include:
Nausea
Vomiting
Mild fever
Injection site discomfort
Skin rash
Allergic reactions (rare)
When used with chemotherapy, additional side effects may occur depending on the accompanying medicines. Seek immediate medical attention if severe allergic reactions, breathing difficulty, or persistent fever develop.

🔹 Precautions
Before using LEUCROIN 5 mL Injection, inform your doctor if you have:
Allergy to leucovorin or folinic acid
Vitamin B12 deficiency–related anemia
Kidney or liver disease
Ongoing chemotherapy treatment
Pregnancy or breastfeeding
Additional precautions:
Use only under medical supervision.
Regular laboratory monitoring may be required.
Inform your doctor about all medicines and supplements you are taking.
Follow the prescribed chemotherapy schedule carefully.